ANTILITHIATIC ACTIVITY AND PHARMACOGNOSTIC STUDIES OF SCOPARIA DULCIS

Main Article Content

Anju Mathew
A Malar Retna

Keywords

Scoparia dulcis, Antibacterial activity, Antilithiatic activity, Calcium oxalate dissolution method, Gas chromatography, mass spectrometry,

Abstract

Scoparia dulcis Linn has been widely reported to have pharmacological uses arising from its wide spread uses. The different extracts were prepared by successive extraction with petroleum ether, chloroform, ethanol and water using soxhlet distillation method. Phytochemical analysis of plant extract revealed the presence of alkaloids, carbohydrates, glycoside, tannins, starch etc.

Thin layer chromatography and Gas chromatography-mass spectrometric analysis revealed the presence of different components in the plant extract. Among the 50 components obtained, 10 important organic compounds were analyzed. All these compounds are found to be having some medicinal application.

UV visible spectroscopic analysis of extract of Scoparia dulcis reported four chromatogram figures which showed prominent peaks having maximum absorption of 666 nm corresponded to wavelength of methylene blue and brilliant blue. FTIR spectroscopic analysis reveals the presence of important functional groups like-OH,-NO2,-SO3,-SH, -COOH, NH2, R-X etc. Antibacterial activity of petroleum ether, chloroform, and ethanol and water extracts of stems and leaves of Scoparia dulcis reveals that chloroform and ethanol extracts shows maximum resistance against Staphylococcus while ethanol and aqueous extracts showed maximum resistance against Klebsiela pneumonia.

The exciting fact came out of the study is that water extract of Scoparia dulcis showed great potential to dissolve the Calcium oxalate crystals ie, the plant extract shows invitro antilithiatic activity for kidney stones. Thus Scoparia dulcis act as a source of different valuable organic compounds that are having medicinal applications and have a beneficial effect on kidney stone problem.

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