FORMULATION OF IN SITU GELLING SYSTEM FOR OPHTHALMIC DELIVERY OF ERYTHROMYCIN
AbstractEye is a unique organ which exerts various limitations for the delivery of drug due to its physiology barriers. Therefore, the posterior part of the eyes remains a major concern for formulation scientists to develop ocular drug delivery system which can overcome the barriers of theeye and provide local or systemic effect with immediate or sustained release dosage forms. Conventional ophthalmic dosage forms such as eye drop, ointment and gel provide low bioavailability and less pre-corneal drug residence time due to nasolacrimal drainage of the eyes. The major challenge is to formulate a system to improve the contact time of the drug in eyes. This is achieved by in situ gel system where the drugs are incorporatedwith various types of polymers which exhibit solution to gel phase transition. An in situ gelling technique provides greater bioavailability by resisting ocular drainage leading to longer residence time. This paper proposes the formulation of in situ gels for effective delivery of Erythromycin used to treat conjunctivitis and to evaluate dosage form characteristic such as pH, gelling capacity, gel strength, sterility testing, drug content, in vitro diffusion study, antibacterial activity and accelerated stability studies to ensure the safety and stability of the dosage form. Hence an attempt will be made to develop novel in situ gelling systems using Erythromycin, antimicrobial agent as a promising alternative to the conventional dosage forms for the effective treatment of various eye infections.
2. Abdul Malik, P.H., and Satyananda, S. (2014). pH- induced in situ gelling system of an anti-infective drug for sustained ocular delivery. Journal of Applied Pharmaceutical Science, 4(1), 101-104.
3. Bhatia HoneyBala, Sachan Ajay, Bhandari Anil. (2013). Studies on thermoreversivemucoadhesive ophthalmic in situ gel of Azithromycin.Journal of Drug Delivery and Therapeutics, 3(5), 106-109.
4. Bharath, S., Sindhu,A., Sharon,F., Basavaraj, B.V., Deveswaran, R., Madhavan, V. (2009).Sustained ophthalmic delivery of Ofloxacin from an ion-activated in situ gelling system.Pakistan Journal of Pharmaceuticals Sciences, 22(2), 175-79.
Eaga Chandra Mohan, Jagan Mohan Kandukuri, VenkateshamAllenki. (2009).Preparation and evaluation of in-situ gels for ocular drug delivery. Journal of Pharmacy Research, 2(6), 1089-1094.
GouravRajoriaandArushi Gupta. (2012). In-situ gelling system: A novel approach for ocular drug delivery.American journal of pharmtech research, 2(4), 25-53.
5. Himanshu Gupta, Aqil Malik,R.K., Khar, Asgar Ali, AseemBhatnagar, Gaurav Mittal. (2015). Physiologically active hydrogel (in situ gel) of Sparfloxacin and its evaluation for ocular retention using gamma scintigraphy. Journal of Pharmacy and Bioallied Science, 7(3), 195-200.https://doi.org/10.4103/0975-7406.160015
6. Himanshu Gupta,M.,Aqil, R.K., Khar, Asgar Ali, AseemBhatnagar, Gaurav Mittal, Sanyog Jain. (2009). Development and characterization of 99mtc-Timolol Maleate for evaluating efficacy of in situ ocular drug delivery system.American Association of Pharmaceutical Scientists, 10(2), 540-546.https://doi.org/10.1208/s12249-009-9238-x
7. KaulShweta, Kumar Ganesh, KothiyalPreeti. (2012). Development and in-Vitro characterization of ocular inserts containing Erythromycin.International Research Journal of Pharmacy, 3(8), 247-250.
8. Kavitha, K., and Rajas, N.J. (2011) Sustained ophthalmic delivery of Levofloxacin hemihydrate from an ion activated in situ gelling system. International Journal of PharmTechResearch, 3(2), 702-706.
9. Lisa,R.,Schopf, Alexey, M., Popov, Elizabeth,M., Enlow, James, L., Bourassa, Winston, Z., Ong, Pawel Nowak, Hongming Chen. (2015).Topical ocular drug delivery to the back of the eye by mucus-penetrating particles.Translational Vision Science & Technology, 4(3), 1-12.
10. Mane Kirti and DholeShashikant.(2014). In-situ gels a novel approach for ocular drug delivery. World Journal of Pharmacy and Pharmaceutical Sciences, 3(8), 317-333.
11. Pallavi, R., Kute, S.B., Gondkar, Saudagar, R.B. (2015). Ophthalmic in-situ gel: An overview. World Journal of Pharmacy and Pharmaceutical Sciences, 4(4), 549-568.
12. RamaiyanDhanapal and VijayaRatna, J. (2012).Ocular drug delivery system– a review.International Journal of Innovative Drug Discovery, 2 (1), 4-15.
13. Rathod, Kinjal, B., Patel, Mandev, B. (2013). Formulation and evaluation of an ion activated in situ gel for ocular delivery of Norfloxacin.World Journal of Pharmacy and Pharmaceutical sciences,2 (6), 5888-5897.
14. Reddy, J.S., and Ahmed, M.G. (2013). Sustained ocular delivery of Sparfloxacin from pH triggered in situ gelling system. Mahidol University Journal of Pharmaceutical Sciences, 40(3), 16-25.
15. Sampath Kumar, K., DebjitBhowmik, P., ShravanPaswan, ShwetaSrivastava. (2012). Recent challenges and advances in ophthalmic drug delivery system. The Pharma Innovation, 1(4), 2-15.
16. Sandeep, C., Atram, Nishan, N., Bobade, Vikrant, P., Wankhade, Dr Shrikant, D., Pande, Dr Kiran, K., Tapar. (2013). Current trends towards an ocular drug delivery system: Review. International Journal of Pharmacy and Pharmaceutical Science Research, 3(1), 28-34.
17. Sindhu Abraham, Sharon Furtado, Bharath, S., Basavaraj, B.V., Deveswaran, R., Madhavan, V. (2009).Sustained ophthalmic delivery of Ofloxacin from an ion-activated in situ gelling system.Pakistan journal of pharmaceuticals sciences, 22(2), 175-179.
18. SuryawanshiSarika, S., Kunjwani, H.K., KawadeJayashree, V., AlkunteMohita, A., YadavDattatraya, J. (2012).Novel polymeric in situ gels for ophthalmic drug delivery system.International Journal of Research in Pharmacy and Science, 2(1), 67-83.
19. Tinu, T.S., LithaThomas, Anil Kumar, B. (2013). Polymers used in ophthalmic in situ gelling system. International Journal of Pharmaceutical Sciences Review and Research, 20(1), 176-183.
20. Yuejiang Liu, Jinpeng Liu, Xiaolin Zhang, Ruodan Zhang, Yongliang Huang, Chunjie Wu. (2012).In situ gelling gelrite/alginate formulations as vehicles for ophthalmic drug delivery.American Association of Pharmaceutical Scientists, 11(2), 610-620.
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