Article Sidebar

Download
PDF
Statistic
Read Counter : 526 Download : 296

Downloads

Download data is not yet available.

Main Article Content

Abstract

Metformin hydrochloride is an oral antihyperglycemic drug used in the management of type-2 diabetes. Inclusion complexes were prepared between Metformin hydrochloride and alpha- cyclodextrin in solid and solution state. Inclusion complexes were characterised using UV-VIS, Fluorescence and FTIR Spectroscopic Studies. Phase solubility studies were carried out which determined the 1:1 stoichiometry for the formation of inclusion complexes.

Keywords

Metformin hydrochloride Antihyperglycemic drug alpha-Cyclodextrin Inclusion complex Phase Solubility

Article Details

Authors retain the copyright without restrictions for their published content in this journal. 

Publishing License

This is an open-access article distributed under the terms of  Creative Commons License

How to Cite
Roselet, S. L., & Premakumari, D. J. (2015). STUDIES ON METFORMIN HYDROCHLORIDE AND ALPHA-CYCLODEXTRIN INCLUSION COMPLEXES. Green Chemistry & Technology Letters, 1(01), 48-53. https://doi.org/10.18510/gctl.2015.117

References

  1. Turro NJ, Okubo T & Chung C, Inclusional Association of a Fluorescence Detergent Probe with Cyclodextrins. Microscopic Environment of the interior of a Cyclodextrin Cavity. Pressure effects, J. Am. Chem. Soc., 104(14), 1982, 3954.
  2. Hamai. S, Association of Inclusion Compounds of β- Cyclodextrin in Aqueous Solution, Bull. Chem. Soc. Jpn., 55, 1982, 2721.
  3. Valerian T. D’ Souza. Kenny B. Lipkowitz, Cyclodextrins: Introduction, Chem. Rev., 98(5), 1998, 1741.
  4. Uekama K, Hirayama F, Irie T, Chem. Rev., 98(5), 1998, 2045.
  5. Huang Naiju, You Chen, Zhang Daodao, Application of Cyclodextrin Inorganic Synthesis, Chin. J. Org. Chem., 6, 1987, 482.
  6. Higuchi. T. Connors K, Phase-Solubility Techniques, Adv. Anal. Chem. Instr., 4, 1965, 212–217.
  7. Yapeng Lu, Siyuan Liu, Yu, Zhao, Li Zhu, Shuqin Yu, Complexation of Z-ligustilide with hydroxypropyl-β- Cyclodextrin to improve stability and oral bioavailability, Acta. Pharm., 64, 2014, 211-222.
  8. Benesi. H. A, Hildebrand J. H., The Benesi-Hildebrand Method for Determination of Kf for DA association and ε values for DA CT absorption, J. Am. Soc., 71, 1949, 2703.
  9. Wang H.Y, Han J, Feng X.G, Spectroscopic study of Orange G-alpha-Cyclodextrin complex and its Analytical Applications, Spectrochim. Acta. A 66, 2007, 578–585.
  10. Wieslawa Misiuk, Spectrofluorimetric Study on Inclusion Interaction of β- Cyclodextrin with duloxetine and its analytical application, Ind. J. Chem., 51A 2012, 1706-1710.
  11. Li. N, Liu. J, Zhao. X, Gao. Y, Zhang. L, Yu. L, Complex formation of ionic liquid surfactanct an alpha-Cyclodextrin, Colloids Surf. A, 292, 2007, 196-201.
  12. Li. W, Lu. B; Sheng. A, Yang. F, Wang. Z, Spectrscopic and theoretical study on inclusion complexation of β- Cyclodextrin with Permethrin, J. Mol. Struct. 981, 2010, 194-203.
  13. Kavirajaa Pandian Sambasevam, Sharifah Mohamed, Norazilawati Muhamad Sarih and Nor Atiqah Ismail, Synthesis and Characterization of the Inclusion complex of β- Cyclodextrin and Azomethine, Int. J. Mol. Sci., 14, 2013, 3671-3682.
  14. Ramnik Singh et al., Characterization of Cyclodextrin Inclusion Complexes-A Review, J. Pharm. Sci & Tech., 2(3), 2010, 171-183.
  15. Mukesh Chandra Sharma & Smita Sharma., Preparation Physiochemical Characterization Dissolution Formulation and Spectroscopic Studies of β- Cyclodextrin Inclusion Complex, Int. J. Chem. Tech. Res., 3(1), 2011, 104-111.