PREPARATION OF HOLLOW TIO2 NANOSPHERES FOR BIOMEDICAL APPLICATIONS

Main Article Content

Himani Kalita
Amita Pathak

Keywords

TiO2, hollow nanospheres, biocompatibility, carbon spheres, anatase, rutile.

Abstract

The present work reports the preparation of hollow TiO2 nanospheres through sacrificial core templating method where, the sacrificial core of carbon spheres were indigenously synthesized and mixed into the starting ethanolic solution of titanium tetraisopropoxide (TTIP) under ambient condition. The solid obtained on the hydrolysis of TTIP were dried and calcined in air to acquire the hollow nanospheres of TiO2 in anatase phase. The acquired samples were further doped with varying mole % of Mn(II) to invoke magnetism in the material. X-ray diffraction and thermal studies reflected the anatase to rutile phase transformation of TiO2 at 550 °C when the dopant (i.e., Mn) concentration was increased from 0 to 6 mol % (with respect to Ti). The hollow and spherical morphology of the TiO2 nanostructures were confirmed through scanning electron microscopic studies while their ferromagnetic behaviour (at 300 K) was affirmed through SQUID analysis. For intracellular applications, the biocompatibility of the nanospheres was tested through conventional MTT assay, performed on MDA-MB 231 cancer cell lines.

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